Infections and cancer risk

Can infections cause cancer?

Many people don’t realise that infections can be associated with cancer, but almost a fifth of cancers worldwide are caused by viral, bacterial or parasitic infections. Those most commonly associated with an increased cancer risk are the human papilloma virus (HPV), hepatitis B (HBV) and C (HCV), and the bacterium Helicobacter pylori (H pylori).

HPV

HPV is a common infection, but there are some high-risk types of the virus which can lead to several cancers, including cervical and anal. It is spread through close skin-to-skin contact, usually during sexual activity. Using a barrier method of contraception reduces the risk. Vaccination is also effective where available: girls in the UK (aged 12–13) and the US (11–12) are offered vaccination against the types of HPV that cause the majority of cervical cancers.

HBV and HCV

Infection with HBV or HCV can cause liver cancer. These can be passed on through blood and other bodily fluids, most commonly through sexual activity or sharing needles to inject drugs. In most countries, young children are offered routine vaccination against HBV. The risk can also be reduced by practising safe sex and not sharing needles.

H pylori

Infection with H pylori, a type of bacterium that grows in the inside layer of the human stomach, is very common worldwide, especially in low- and middle-income countries. Usually acquired during childhood, it is spread through contaminated food and water, and direct mouth-to-mouth contact. It increases the risk of stomach cancer. It can also cause stomach ulcers. Infection with H pylori can be treated, so it’s important to talk to your doctor if you have stomach problems or ulcers.

HIV

People infected with the human immunodeficiency virus (HIV) are also at an increased risk of some cancers, including Kaposi sarcoma, lymphoma, liver and lung. Treatment for HIV is available, so anyone who thinks they are at risk should talk to their doctor about being tested.


Sources